null
SMILES: COc1cccc2OC(c3cc(Cl)cc(Cl)c3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12
InChI Key: InChIKey=UTLVNNNRCCRBDZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for glucocorticoid receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for glucocorticoid receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for glucocorticoid receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for progesterone receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for progesterone receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for mineralocorticoid receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for androgen receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to dexamethasone | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Repression activity of GR ligand with interleukin-6 receptor in native cell assay using dexamethasone was determined as maximal potency | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Transcriptional activation in CV-1 cells expressing glucocorticoid receptor | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Transcriptional repression of IL-1 stimulated IL-6 expression in native cells compared to dexamethasone | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50103251 (5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Glucocorticoid-induced aromatase activity in human skin fibroblasts | J Med Chem 44: 2879-85 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6RJP | |||||||||||
More data for this Ligand-Target Pair |