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BDBM50104467 CHEMBL437042::{[(R)-1-{12-[(2-Chloro-phenoxy)-hydroxy-phosphoryloxy]-dodecylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamic acid benzyl ester; compound with triethyl-amine

SMILES: OP(=O)(OCCCCCCCCCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OCc1ccccc1)Oc1ccccc1Cl

InChI Key: InChIKey=GEEJZLGSINTQLI-PGUFJCEWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50104467   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))		BDBM50104467
PNG
(CHEMBL437042 | {[(R)-1-{12-[(2-Chloro-phenoxy)-hyd...)
Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OCc1ccccc1)Oc1ccccc1Cl
Show InChI InChI=1S/C39H50ClN4O8P/c40-33-21-13-15-23-36(33)52-53(48,49)51-25-17-8-6-4-2-1-3-5-7-16-24-41-38(46)35(26-31-27-42-34-22-14-12-20-32(31)34)44-37(45)28-43-39(47)50-29-30-18-10-9-11-19-30/h9-15,18-23,27,35,42H,1-8,16-17,24-26,28-29H2,(H,41,46)(H,43,47)(H,44,45)(H,48,49)/t35-/m1/s1
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Similars
PubMed
n/an/a 1.21E+4n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase extracted from HCT 116 cell lines

Bioorg Med Chem Lett 11: 2581-4 (2001)


BindingDB Entry DOI: 10.7270/Q2XD10Z2
More data for this
Ligand-Target Pair