BindingDB PrimarySearch

BDBM50104974 2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 8-carbamoylmethyl-amide 12-hydroxyamide::CHEMBL115263

SMILES: NC(=O)CNC(=O)[C@@H]1CCCCNC(=O)OCCC[C@@H]([C@@H](Cc2ccc(cc2)-c2ccccc2C(F)(F)F)C(=O)N1)C(=O)NO

InChI Key: InChIKey=SOPDPCOBVSOXIM-ZDXQCDESSA-N

Data: 13 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50104974
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ADAM17 (Sus scrofa (pig))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of porcine TNF-alpha converting enzyme(pTACE).				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	428	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-8				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	442	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-13				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-7				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.87E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-2				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-1				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-3				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 10 (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-10				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of human matrix metalloprotease-9				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-14				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 16 (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-16				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-12				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 15 (Homo sapiens (Human))	BDBM50104974 (2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-15				J Med Chem 44: 3351-4 (2001) BindingDB Entry DOI: 10.7270/Q2VD6XRT
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair