BDBM50104991 4-tert-Butyl-N-[6-[2-(5-chloro-pyrimidin-2-yloxy)-ethoxy]-5-(3-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide::CHEMBL114964
SMILES: COc1cccc(Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)ncnc2OCCOc2ncc(Cl)cn2)c1
InChI Key: InChIKey=POKACOFNIMWICU-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelin receptor ET-A (Sus scrofa) | BDBM50104991 (4-tert-Butyl-N-[6-[2-(5-chloro-pyrimidin-2-yloxy)-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0590 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells | J Med Chem 44: 3355-68 (2001) BindingDB Entry DOI: 10.7270/Q2QN662B | |||||||||||
More data for this Ligand-Target Pair |