BDBM50105027 CHEMBL176272::sodium salt of 4-tert-Butyl-N-{6-[2-(5-chloro-pyrimidin-2-yloxy)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-benzenesulfonamide
SMILES: Cc1ccc(cc1)-c1c([N-]S(=O)(=O)c2ccc(cc2)C(C)(C)C)ncnc1OCCOc1ncc(Cl)cn1
InChI Key: InChIKey=HLZRFVXMFALVBN-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EDNRB (Homo sapiens (Human)) | BDBM50105027 (CHEMBL176272 | sodium salt of 4-tert-Butyl-N-{6-[2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description In vitro for specific binding of [125I]-ET-1 to GHcell expressed in Endothelin B receptor | J Med Chem 44: 3355-68 (2001) BindingDB Entry DOI: 10.7270/Q2QN662B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRA (RAT) | BDBM50105027 (CHEMBL176272 | sodium salt of 4-tert-Butyl-N-{6-[2...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells | J Med Chem 44: 3355-68 (2001) BindingDB Entry DOI: 10.7270/Q2QN662B | |||||||||||
More data for this Ligand-Target Pair |