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BDBM50105042 4-tert-Butyl-N-{6-[2-(pyrimidin-2-yloxy)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-benzenesulfonamide::CHEMBL321242

SMILES: Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ncnc1OCCOc1ncccn1

InChI Key: InChIKey=CSOLXVHPESVFGU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105042   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelin receptor ET-A


(Sus scrofa)		BDBM50105042
PNG
(4-tert-Butyl-N-{6-[2-(pyrimidin-2-yloxy)-ethoxy]-5...)
Show SMILES Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ncnc1OCCOc1ncccn1
Show InChI InChI=1S/C27H29N5O4S/c1-19-6-8-20(9-7-19)23-24(32-37(33,34)22-12-10-21(11-13-22)27(2,3)4)30-18-31-25(23)35-16-17-36-26-28-14-5-15-29-26/h5-15,18H,16-17H2,1-4H3,(H,30,31,32)
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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 0.110n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells

J Med Chem 44: 3355-68 (2001)


BindingDB Entry DOI: 10.7270/Q2QN662B
More data for this
Ligand-Target Pair