BDBM50105043 1,2,3,4-Tetrahydro-fluoren-9-one salt ofN-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-4-chloro-benzenesulfonamide::CHEMBL175931

SMILES: Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(Cl)cc2)ncnc1OCCOc1ncc(Br)cn1

InChI Key: InChIKey=UAJKFNZFRYXVSB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105043   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelin receptor ET-A (Sus scrofa)	BDBM50105043 (1,2,3,4-Tetrahydro-fluoren-9-one salt ofN-{6-[2-(5...) Show SMILES Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(Cl)cc2)ncnc1OCCOc1ncc(Br)cn1 Show InChI InChI=1S/C23H19BrClN5O4S/c1-15-2-4-16(5-3-15)20-21(30-35(31,32)19-8-6-18(25)7-9-19)28-14-29-22(20)33-10-11-34-23-26-12-17(24)13-27-23/h2-9,12-14H,10-11H2,1H3,(H,28,29,30)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells				J Med Chem 44: 3355-68 (2001) BindingDB Entry DOI: 10.7270/Q2QN662B
					More data for this Ligand-Target Pair