BDBM50105236 6-Chloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid (1-benzyl-2-oxo-ethyl)-amide::CHEMBL117553

SMILES: CN1C(Cc2cc(Cl)ccc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O

InChI Key: InChIKey=ICVMQKWIUIJYIR-BHWOMJMDSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50105236   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calpain1 (Homo sapiens (Human))	BDBM50105236 (6-Chloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1la...) Show SMILES CN1C(Cc2cc(Cl)ccc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C19H19ClN2O4S/c1-22-17(11-14-10-15(20)7-8-18(14)27(22,25)26)19(24)21-16(12-23)9-13-5-3-2-4-6-13/h2-8,10,12,16-17H,9,11H2,1H3,(H,21,24)/t16-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory activity towards human calpain I				J Med Chem 44: 3488-503 (2001) BindingDB Entry DOI: 10.7270/Q2G44PKR
					More data for this Ligand-Target Pair
Calpain1 (Homo sapiens (Human))	BDBM50105236 (6-Chloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1la...) Show SMILES CN1C(Cc2cc(Cl)ccc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C19H19ClN2O4S/c1-22-17(11-14-10-15(20)7-8-18(14)27(22,25)26)19(24)21-16(12-23)9-13-5-3-2-4-6-13/h2-8,10,12,16-17H,9,11H2,1H3,(H,21,24)/t16-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against MOLT-4 cells (human T-cell leukemia cell line)				J Med Chem 44: 3488-503 (2001) BindingDB Entry DOI: 10.7270/Q2G44PKR
					More data for this Ligand-Target Pair
Calpain1 (Homo sapiens (Human))	BDBM50105236 (6-Chloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1la...) Show SMILES CN1C(Cc2cc(Cl)ccc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C19H19ClN2O4S/c1-22-17(11-14-10-15(20)7-8-18(14)27(22,25)26)19(24)21-16(12-23)9-13-5-3-2-4-6-13/h2-8,10,12,16-17H,9,11H2,1H3,(H,21,24)/t16-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory activity towards human calpain I				J Med Chem 44: 3488-503 (2001) BindingDB Entry DOI: 10.7270/Q2G44PKR
					More data for this Ligand-Target Pair