BDBM50105241 6,7-Dichloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid (1-benzyl-2-oxo-ethyl)-amide::CHEMBL118688

SMILES: CN1C(Cc2cc(Cl)c(Cl)cc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O

InChI Key: InChIKey=WGAWTZRUUNHJGZ-MBIQTGHCSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50105241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calpain1 (Homo sapiens (Human))	BDBM50105241 (6,7-Dichloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro...) Show SMILES CN1C(Cc2cc(Cl)c(Cl)cc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C19H18Cl2N2O4S/c1-23-17(9-13-8-15(20)16(21)10-18(13)28(23,26)27)19(25)22-14(11-24)7-12-5-3-2-4-6-12/h2-6,8,10-11,14,17H,7,9H2,1H3,(H,22,25)/t14-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory activity towards human calpain I				J Med Chem 44: 3488-503 (2001) BindingDB Entry DOI: 10.7270/Q2G44PKR
					More data for this Ligand-Target Pair
Calpain1 (Homo sapiens (Human))	BDBM50105241 (6,7-Dichloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro...) Show SMILES CN1C(Cc2cc(Cl)c(Cl)cc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C19H18Cl2N2O4S/c1-23-17(9-13-8-15(20)16(21)10-18(13)28(23,26)27)19(25)22-14(11-24)7-12-5-3-2-4-6-12/h2-6,8,10-11,14,17H,7,9H2,1H3,(H,22,25)/t14-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory activity towards human calpain I				J Med Chem 44: 3488-503 (2001) BindingDB Entry DOI: 10.7270/Q2G44PKR
					More data for this Ligand-Target Pair
Calpain1 (Homo sapiens (Human))	BDBM50105241 (6,7-Dichloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro...) Show SMILES CN1C(Cc2cc(Cl)c(Cl)cc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C19H18Cl2N2O4S/c1-23-17(9-13-8-15(20)16(21)10-18(13)28(23,26)27)19(25)22-14(11-24)7-12-5-3-2-4-6-12/h2-6,8,10-11,14,17H,7,9H2,1H3,(H,22,25)/t14-,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against MOLT-4 cells (human T-cell leukemia cell line)				J Med Chem 44: 3488-503 (2001) BindingDB Entry DOI: 10.7270/Q2G44PKR
					More data for this Ligand-Target Pair