BDBM50105308 CHEMBL3597784

SMILES: Fc1cc(Br)cc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1

InChI Key: InChIKey=YTLPDXKPGXINAV-LSDHHAIUSA-N

Data: 2 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50105308   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human))	BDBM50105308 (CHEMBL3597784) Show SMILES Fc1cc(Br)cc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1 |r| Show InChI InChI=1S/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center Curated by ChEMBL					Assay Description Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysis				J Med Chem 58: 5930-41 (2015) BindingDB Entry DOI: 10.7270/Q2G162K1
					More data for this Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50105308 (CHEMBL3597784) Show SMILES Fc1cc(Br)cc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1 |r| Show InChI InChI=1S/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center Curated by ChEMBL					Assay Description Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...				J Med Chem 58: 5930-41 (2015) BindingDB Entry DOI: 10.7270/Q2G162K1
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human))	BDBM50105308 (CHEMBL3597784) Show SMILES Fc1cc(Br)cc(c1)[C@@H]1C[C@H](c2ccccc2)n2nnnc2N1 |r| Show InChI InChI=1S/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center Curated by ChEMBL					Assay Description Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...				J Med Chem 58: 5930-41 (2015) BindingDB Entry DOI: 10.7270/Q2G162K1
					More data for this Ligand-Target Pair