BDBM50105599 5-Bromomethyl-3-(3-p-tolyl-ureido)-thiophene-2-carboxylic acid methyl ester::CHEMBL96383::methyl 5-(bromomethyl)-3-(3-p-tolylureido)thiophene-2-carboxylate

SMILES: COC(=O)c1sc(CBr)cc1NC(=O)Nc1ccc(C)cc1

InChI Key: InChIKey=PEADCOWIDLRFLC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50105599   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105599 (5-Bromomethyl-3-(3-p-tolyl-ureido)-thiophene-2-car...) Show SMILES COC(=O)c1sc(CBr)cc1NC(=O)Nc1ccc(C)cc1 Show InChI InChI=1S/C15H15BrN2O3S/c1-9-3-5-10(6-4-9)17-15(20)18-12-7-11(8-16)22-13(12)14(19)21-2/h3-7H,8H2,1-2H3,(H2,17,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory concentration against raf kinase.				Bioorg Med Chem Lett 11: 2775-8 (2001) BindingDB Entry DOI: 10.7270/Q2NS0VD5
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105599 (5-Bromomethyl-3-(3-p-tolyl-ureido)-thiophene-2-car...) Show SMILES COC(=O)c1sc(CBr)cc1NC(=O)Nc1ccc(C)cc1 Show InChI InChI=1S/C15H15BrN2O3S/c1-9-3-5-10(6-4-9)17-15(20)18-12-7-11(8-16)22-13(12)14(19)21-2/h3-7H,8H2,1-2H3,(H2,17,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of B-Raf1 (unknown origin)				Eur J Med Chem 44: 1240-9 (2009) Article DOI: 10.1016/j.ejmech.2008.09.016 BindingDB Entry DOI: 10.7270/Q28G8KJ5
					More data for this Ligand-Target Pair