BDBM50105619 1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl)-urea::1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)urea::CHEMBL94487

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1

InChI Key: InChIKey=ANWRKPQVLGBTCG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50105619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105619 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 Show InChI InChI=1S/C20H21N3O3/c1-20(2,3)17-13-18(23-26-17)22-19(24)21-14-9-11-16(12-10-14)25-15-7-5-4-6-8-15/h4-13H,1-3H3,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against human Raf-1 kinase				Bioorg Med Chem Lett 14: 783-6 (2004) BindingDB Entry DOI: 10.7270/Q2TM79JT
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105619 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 Show InChI InChI=1S/C20H21N3O3/c1-20(2,3)17-13-18(23-26-17)22-19(24)21-14-9-11-16(12-10-14)25-15-7-5-4-6-8-15/h4-13H,1-3H3,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory concentration against raf kinase.				Bioorg Med Chem Lett 11: 2775-8 (2001) BindingDB Entry DOI: 10.7270/Q2NS0VD5
					More data for this Ligand-Target Pair
MAP kinase p38 (Homo sapiens (Human))	BDBM50105619 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 Show InChI InChI=1S/C20H21N3O3/c1-20(2,3)17-13-18(23-26-17)22-19(24)21-14-9-11-16(12-10-14)25-15-7-5-4-6-8-15/h4-13H,1-3H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of Escherichia coli derived Mitogen-activated protein kinase p38				Bioorg Med Chem Lett 11: 2775-8 (2001) BindingDB Entry DOI: 10.7270/Q2NS0VD5
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105619 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 Show InChI InChI=1S/C20H21N3O3/c1-20(2,3)17-13-18(23-26-17)22-19(24)21-14-9-11-16(12-10-14)25-15-7-5-4-6-8-15/h4-13H,1-3H3,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of B-Raf1 (unknown origin)				Eur J Med Chem 44: 1240-9 (2009) Article DOI: 10.1016/j.ejmech.2008.09.016 BindingDB Entry DOI: 10.7270/Q28G8KJ5
					More data for this Ligand-Target Pair