BDBM50105621 5-tert-Butyl-3-[3-(5-cyclopropyl-[1,3,4]thiadiazol-2-yl)-ureido]-thiophene-2-carboxylic acid methyl ester::CHEMBL96793

SMILES: COC(=O)c1sc(cc1NC(=O)Nc1nnc(s1)C1CC1)C(C)(C)C

InChI Key: InChIKey=AFBGBORDJVRQJT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105621 (5-tert-Butyl-3-[3-(5-cyclopropyl-[1,3,4]thiadiazol...) Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1nnc(s1)C1CC1)C(C)(C)C Show InChI InChI=1S/C16H20N4O3S2/c1-16(2,3)10-7-9(11(24-10)13(21)23-4)17-14(22)18-15-20-19-12(25-15)8-5-6-8/h7-8H,5-6H2,1-4H3,(H2,17,18,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory concentration against raf kinase.				Bioorg Med Chem Lett 11: 2775-8 (2001) BindingDB Entry DOI: 10.7270/Q2NS0VD5
					More data for this Ligand-Target Pair