BDBM50106239 6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-carboxamidine::CHEMBL127909
SMILES: NC(=N)c1cc2cc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O
InChI Key: InChIKey=NKADRYHVDUCFQU-UHFFFAOYSA-N
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description The compound was tested for inhibition of human urokinase type plasminogen activator (microPa) | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tissue-type plasminogen activator (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description The compound was tested for inhibition of human plasmin | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor VII (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description The compound was tested for inhibition of human coagulation factor VII | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin II (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description The compound was tested for inhibition of human trypsin | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Binding affinity against human coagulation factor X | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tissue-type plasminogen activator (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description The compound was tested for inhibition of human tissue plasminogen activator | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50106239 (6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Inc. Curated by ChEMBL | Assay Description The compound was tested for inhibition of human thrombin | J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR | |||||||||||
More data for this Ligand-Target Pair |