BDBM50106243 2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-carboxamidine::CHEMBL127278

SMILES: Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O

InChI Key: InChIKey=QRPASZARTYLGAR-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50106243   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human plasmin				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Trypsin II (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human trypsin				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Coagulation factor VII (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human coagulation factor VII				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human tissue plasminogen activator				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity against human coagulation factor X				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50106243 (2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...) Show SMILES Cc1cc2[nH]c(cc2cc1C(N)=N)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C22H19N3O/c1-13-10-19-15(11-18(13)22(23)24)12-20(25-19)17-9-5-8-16(21(17)26)14-6-3-2-4-7-14/h2-12,25-26H,1H3,(H3,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human thrombin				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair