BDBM50106307 2-Phenyl-2,3-dihydro-1H-quinazolin-4-one::CHEMBL129312
SMILES: O=C1NC(Nc2ccccc12)c1ccccc1
InChI Key: InChIKey=BIVGFFFLVZMILM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cathepsin H (Capra hircus (Goat)) | BDBM50106307 (2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Kurukshetra University | Assay Description Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was... | Bioorg Chem 59: 12-22 (2015) Article DOI: 10.1016/j.bioorg.2015.01.005 BindingDB Entry DOI: 10.7270/Q2DZ071B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Capra hircus (Goat)) | BDBM50106307 (2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.11E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Kurukshetra University | Assay Description Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was... | Bioorg Chem 59: 12-22 (2015) Article DOI: 10.1016/j.bioorg.2015.01.005 BindingDB Entry DOI: 10.7270/Q2DZ071B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50106307 (2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assay | Bioorg Med Chem 23: 4139-49 (2015) Article DOI: 10.1016/j.bmc.2015.06.063 BindingDB Entry DOI: 10.7270/Q2W66NJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50106307 (2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assay | Bioorg Med Chem 23: 4139-49 (2015) Article DOI: 10.1016/j.bmc.2015.06.063 BindingDB Entry DOI: 10.7270/Q2W66NJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin (Sus scrofa (Pig)) | BDBM50106307 (2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization.(ITP) | J Med Chem 44: 3932-6 (2001) BindingDB Entry DOI: 10.7270/Q2PK0FFW | |||||||||||
More data for this Ligand-Target Pair |