BindingDB PrimarySearch

BDBM50106431 1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoline-3-carboxylic acid::CHEMBL292700

SMILES: OC(=O)c1cc2cc(O)c(O)cc2c(n1)C(=O)c1ccc(O)c(O)c1

InChI Key: InChIKey=ZCMFEWUYBFMLIN-UHFFFAOYSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50106431
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin-like growth factor binding protein 4 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 4				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 2 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against insulin-like growth factor binding protein 2				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 1 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against insulin-like growth factor binding protein 1				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 5				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 3 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 5 (IGFBP-5)				Bioorg Med Chem Lett 13: 1931-4 (2003) BindingDB Entry DOI: 10.7270/Q2XD1138
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 3 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)				Bioorg Med Chem Lett 13: 1927-30 (2003) BindingDB Entry DOI: 10.7270/Q2251HK5
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 6 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 6				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair