BDBM50106482 CHEMBL339980::N-[3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-yl]-4-fluoro-benzamide
SMILES: CN(C)CCc1c(C)[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12
InChI Key: InChIKey=WMCLJWPYJWRZJT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 265 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined using [3H]-5-HT as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (5-HT4) (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 4 receptor using [3H]5-HT as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 676 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 2A receptor using [125I]DOI as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor using [3H]LSD as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-HT2C receptor was determined using [125I]- DOI as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >4.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1E receptor was determined using [3H]5-HT as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (RAT) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards rat dopamine D2 receptor was determined using [3H]raclopride as radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (RAT) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards rat dopamine receptor D1 was determined using [3H]SCH-23390 radioligand | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50106482 (CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor | J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B | |||||||||||
More data for this Ligand-Target Pair |