BDBM50107283 AAT-007::CJ-023::GRAPIPRANT::Grapiprant::MR-10A7::RQ-00000007::RQ-7
SMILES: CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
InChI Key: InChIKey=HZVLFTCYCLXTGV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid EP4 receptor (Rattus norvegicus) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at rat recombinant EP4 receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E receptor 4 (Canis lupus familiaris) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at dog recombinant EP4 receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 448 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at human EP4 receptor | Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 449 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... | Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane A2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human platelet TP receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human EP1 receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human FP receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human IP receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human EP2 receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc. Curated by ChEMBL | Assay Description Antagonist activity at human EP3 receptor | Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretrea... | Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation | Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by... | Bioorg Med Chem Lett 26: 2303-7 (2016) BindingDB Entry DOI: 10.7270/Q22F7QBJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubat... | Bioorg Med Chem Lett 26: 2303-7 (2016) BindingDB Entry DOI: 10.7270/Q22F7QBJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mi... | Bioorg Med Chem Lett 26: 931-5 (2016) BindingDB Entry DOI: 10.7270/Q22F7Q93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 689 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... | Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 3... | Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50107283 (AAT-007 | CJ-023 | GRAPIPRANT | Grapiprant | MR-10...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scinti... | Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79 | |||||||||||
More data for this Ligand-Target Pair |