BDBM50107359 5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL140336

SMILES: CCCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key: InChIKey=FPIHUZAABXEZHI-UHFFFAOYSA-N

Data: 2 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107359   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50107359 (5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES CCCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:23| Show InChI InChI=1S/C24H29NO2/c1-6-7-9-20-23-16(22-18(26-5)10-8-11-19(22)27-20)12-13-17-21(23)15(2)14-24(3,4)25-17/h8,10-14,20,25H,6-7,9H2,1-5H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-Dexamethasone				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50107359 (5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES CCCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:23| Show InChI InChI=1S/C24H29NO2/c1-6-7-9-20-23-16(22-18(26-5)10-8-11-19(22)27-20)12-13-17-21(23)15(2)14-24(3,4)25-17/h8,10-14,20,25H,6-7,9H2,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50107359 (5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES CCCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:23| Show InChI InChI=1S/C24H29NO2/c1-6-7-9-20-23-16(22-18(26-5)10-8-11-19(22)27-20)12-13-17-21(23)15(2)14-24(3,4)25-17/h8,10-14,20,25H,6-7,9H2,1-5H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	122	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50107359 (5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES CCCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:23| Show InChI InChI=1S/C24H29NO2/c1-6-7-9-20-23-16(22-18(26-5)10-8-11-19(22)27-20)12-13-17-21(23)15(2)14-24(3,4)25-17/h8,10-14,20,25H,6-7,9H2,1-5H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	405	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair