BDBM50107480 CHEMBL348243::N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-benzylsulfanyl)-4-oxo-5-(2-piperazin-1-yl-pyrimidin-5-ylmethyl)-4H-pyrimidin-1-yl]-N-methyl-acetamide

SMILES: CN(Cc1ccc(cc1)-c1ccc(Cl)cc1)C(=O)Cn1cc(Cc2cnc(nc2)N2CCNCC2)c(=O)nc1SCc1ccc(F)cc1

InChI Key: InChIKey=WWNRZILQEZDLPA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50107480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
LDL-associated phospholipase A2 (Homo sapiens (Human))	BDBM50107480 (CHEMBL348243 | N-(4'-Chloro-biphenyl-4-ylmethyl)-2...) Show SMILES CN(Cc1ccc(cc1)-c1ccc(Cl)cc1)C(=O)Cn1cc(Cc2cnc(nc2)N2CCNCC2)c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C36H35ClFN7O2S/c1-43(21-25-2-6-28(7-3-25)29-8-10-31(37)11-9-29)33(46)23-45-22-30(18-27-19-40-35(41-20-27)44-16-14-39-15-17-44)34(47)42-36(45)48-24-26-4-12-32(38)13-5-26/h2-13,19-20,22,39H,14-18,21,23-24H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).				Bioorg Med Chem Lett 12: 51-5 (2001) BindingDB Entry DOI: 10.7270/Q2862FR5
					More data for this Ligand-Target Pair