BDBM50107490 CHEMBL348030::N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-benzylsulfanyl)-4-oxo-5-(2-oxo-1,2-dihydro-pyrimidin-5-ylmethyl)-4H-pyrimidin-1-yl]-N-methyl-acetamide

SMILES: CN(Cc1ccc(cc1)-c1ccc(Cl)cc1)C(=O)Cn1cc(Cc2cnc(=O)[nH]c2)c(=O)nc1SCc1ccc(F)cc1

InChI Key: InChIKey=DHOSIXDVMOFPLA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50107490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
LDL-associated phospholipase A2 (Homo sapiens (Human))	BDBM50107490 (CHEMBL348030 | N-(4'-Chloro-biphenyl-4-ylmethyl)-2...) Show SMILES CN(Cc1ccc(cc1)-c1ccc(Cl)cc1)C(=O)Cn1cc(Cc2cnc(=O)[nH]c2)c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C32H27ClFN5O3S/c1-38(17-21-2-6-24(7-3-21)25-8-10-27(33)11-9-25)29(40)19-39-18-26(14-23-15-35-31(42)36-16-23)30(41)37-32(39)43-20-22-4-12-28(34)13-5-22/h2-13,15-16,18H,14,17,19-20H2,1H3,(H,35,36,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).				Bioorg Med Chem Lett 12: 51-5 (2001) BindingDB Entry DOI: 10.7270/Q2862FR5
					More data for this Ligand-Target Pair