BDBM50107501 CHEMBL155227::N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[5-(1-ethyl-2-oxo-1,2-dihydro-pyrimidin-5-ylmethyl)-2-(4-fluoro-benzylsulfanyl)-4-oxo-4H-pyrimidin-1-yl]-N-methyl-acetamide

SMILES: CCn1cc(Cc2cn(CC(=O)N(C)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O

InChI Key: InChIKey=MAALXUIAYAMCIJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50107501   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
LDL-associated phospholipase A2 (Homo sapiens (Human))	BDBM50107501 (CHEMBL155227 | N-(4'-Chloro-biphenyl-4-ylmethyl)-2...) Show SMILES CCn1cc(Cc2cn(CC(=O)N(C)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O Show InChI InChI=1S/C34H31ClFN5O3S/c1-3-40-19-25(17-37-33(40)44)16-28-20-41(34(38-32(28)43)45-22-24-6-14-30(36)15-7-24)21-31(42)39(2)18-23-4-8-26(9-5-23)27-10-12-29(35)13-11-27/h4-15,17,19-20H,3,16,18,21-22H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).				Bioorg Med Chem Lett 12: 51-5 (2001) BindingDB Entry DOI: 10.7270/Q2862FR5
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