BindingDB PrimarySearch

BDBM50107609 5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin::CHEMBL2170855::CHEMBL337559::TMPYP4::TMPyP4

SMILES: C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc1n2

InChI Key: InChIKey=ABCGFHPGHXSVKI-LWQDQPMZSA-O

Data: 13 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50107609
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fe-S helicase (FANCJ) (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	8.0	n/a
National Institutes of Health, National Institutes of Health Biomedical Research Center					Assay Description Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...				J Biol Chem 288: 28217-29 (2013) Article DOI: 10.1074/jbc.M113.496463 BindingDB Entry DOI: 10.7270/Q2FT8JVS
					More data for this Ligand-Target Pair
Fe-S helicase (FANCJ) (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	8.0	n/a
National Institutes of Health, National Institutes of Health Biomedical Research Center					Assay Description Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...				J Biol Chem 288: 28217-29 (2013) Article DOI: 10.1074/jbc.M113.496463 BindingDB Entry DOI: 10.7270/Q2FT8JVS
					More data for this Ligand-Target Pair
Fe-S helicase (FANCJ) (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	8.0	n/a
National Institutes of Health, National Institutes of Health Biomedical Research Center					Assay Description Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...				J Biol Chem 288: 28217-29 (2013) Article DOI: 10.1074/jbc.M113.496463 BindingDB Entry DOI: 10.7270/Q2FT8JVS
					More data for this Ligand-Target Pair
DNA-damage-inducible protein G (DinG) (Escherichia coli (Enterobacteria))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	8.0	n/a
National Institutes of Health, National Institutes of Health Biomedical Research Center					Assay Description Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...				J Biol Chem 288: 28217-29 (2013) Article DOI: 10.1074/jbc.M113.496463 BindingDB Entry DOI: 10.7270/Q2FT8JVS
					More data for this Ligand-Target Pair
DNA-damage-inducible protein G (DinG) (Escherichia coli (Enterobacteria))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	8.0	n/a
National Institutes of Health, National Institutes of Health Biomedical Research Center					Assay Description Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...				J Biol Chem 288: 28217-29 (2013) Article DOI: 10.1074/jbc.M113.496463 BindingDB Entry DOI: 10.7270/Q2FT8JVS
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibition of telomerase (unknown origin) by TRAP-LIG assay				J Med Chem 51: 7751-67 (2008) Article DOI: 10.1021/jm801245v BindingDB Entry DOI: 10.7270/Q2CN73SS
University of London Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL					Assay Description Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay				Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas at Austin Curated by ChEMBL					Assay Description Apparent telomerase inhibition by G-quadruplex mechanism				J Med Chem 44: 4509-23 (2001) BindingDB Entry DOI: 10.7270/Q25Q4WVW
University of Texas at Austin Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas at Austin Curated by ChEMBL					Assay Description Apparent telomerase inhibition by G-quadruplex mechanism				J Med Chem 44: 4509-23 (2001) BindingDB Entry DOI: 10.7270/Q25Q4WVW
University of Texas at Austin Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL					Assay Description Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assay				Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL					Assay Description Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay				Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50107609 (5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin \| C...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas at Austin Curated by ChEMBL					Assay Description Apparent telomerase inhibition by G-quadruplex mechanism				J Med Chem 44: 4509-23 (2001) BindingDB Entry DOI: 10.7270/Q25Q4WVW
University of Texas at Austin Curated by ChEMBL					More data for this Ligand-Target Pair