BDBM50107776 4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-benzylamino-indan-5-yl)-amide::CHEMBL142519
SMILES: FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2CC(Cc2c1)NCc1ccccc1
InChI Key: InChIKey=XVGZFRXMWRNZPQ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Microsomal triglyceride transfer protein (Homo sapiens (Human)) | BDBM50107776 (4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Reasearch Curated by ChEMBL | Assay Description In vitro inhibitory activity against MTP using MTP transfer assay | J Med Chem 44: 4677-87 (2001) BindingDB Entry DOI: 10.7270/Q23F4NXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apolipoprotein B-100 (Homo sapiens (Human)) | BDBM50107776 (4'-Trifluoromethyl-biphenyl-2-carboxylic acid (2-b...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Reasearch Curated by ChEMBL | Assay Description Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM | J Med Chem 44: 4677-87 (2001) BindingDB Entry DOI: 10.7270/Q23F4NXH | |||||||||||
More data for this Ligand-Target Pair |