BDBM50107794 CHEMBL356937::{5-[(4,4'-Bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester
SMILES: COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(ccc3-c3ccc(cc3)C(F)(F)F)C(F)(F)F)cc2C1
InChI Key: InChIKey=ZPTKJYMGKHTPFV-FQEVSTJZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Apolipoprotein B-100 (Homo sapiens (Human)) | BDBM50107794 (CHEMBL356937 | {5-[(4,4'-Bis-trifluoromethyl-biphe...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Reasearch Curated by ChEMBL | Assay Description Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM | J Med Chem 44: 4677-87 (2001) BindingDB Entry DOI: 10.7270/Q23F4NXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microsomal triglyceride transfer protein (Homo sapiens (Human)) | BDBM50107794 (CHEMBL356937 | {5-[(4,4'-Bis-trifluoromethyl-biphe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Reasearch Curated by ChEMBL | Assay Description In vitro inhibitory activity against MTP using MTP transfer assay | J Med Chem 44: 4677-87 (2001) BindingDB Entry DOI: 10.7270/Q23F4NXH | |||||||||||
More data for this Ligand-Target Pair |