BDBM50107814 CHEMBL142731::{5-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester
SMILES: COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cc2C1
InChI Key: InChIKey=XIPGMFZCORQMAY-HXUWFJFHSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Microsomal triglyceride transfer protein (Homo sapiens (Human)) | BDBM50107814 (CHEMBL142731 | {5-[(4'-Trifluoromethyl-biphenyl-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Reasearch Curated by ChEMBL | Assay Description In vitro inhibitory activity against MTP using MTP transfer assay | J Med Chem 44: 4677-87 (2001) BindingDB Entry DOI: 10.7270/Q23F4NXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apolipoprotein B-100 (Homo sapiens (Human)) | BDBM50107814 (CHEMBL142731 | {5-[(4'-Trifluoromethyl-biphenyl-2-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Reasearch Curated by ChEMBL | Assay Description Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM | J Med Chem 44: 4677-87 (2001) BindingDB Entry DOI: 10.7270/Q23F4NXH | |||||||||||
More data for this Ligand-Target Pair |