BDBM50109019 Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazol-8-ylmethyl)-amine::CHEMBL313851

SMILES: FC(F)(F)c1nc2ccc3CCC(CNCc4ccccc4)Oc3c2[nH]1

InChI Key: InChIKey=JFFIIIVILGKQSZ-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109019   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50109019 (Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chrom...) Show SMILES FC(F)(F)c1nc2ccc3CCC(CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C19H18F3N3O/c20-19(21,22)18-24-15-9-7-13-6-8-14(26-17(13)16(15)25-18)11-23-10-12-4-2-1-3-5-12/h1-5,7,9,14,23H,6,8,10-11H2,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50109019 (Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chrom...) Show SMILES FC(F)(F)c1nc2ccc3CCC(CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C19H18F3N3O/c20-19(21,22)18-24-15-9-7-13-6-8-14(26-17(13)16(15)25-18)11-23-10-12-4-2-1-3-5-12/h1-5,7,9,14,23H,6,8,10-11H2,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperone				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50109019 (Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chrom...) Show SMILES FC(F)(F)c1nc2ccc3CCC(CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C19H18F3N3O/c20-19(21,22)18-24-15-9-7-13-6-8-14(26-17(13)16(15)25-18)11-23-10-12-4-2-1-3-5-12/h1-5,7,9,14,23H,6,8,10-11H2,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50109019 (Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chrom...) Show SMILES FC(F)(F)c1nc2ccc3CCC(CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C19H18F3N3O/c20-19(21,22)18-24-15-9-7-13-6-8-14(26-17(13)16(15)25-18)11-23-10-12-4-2-1-3-5-12/h1-5,7,9,14,23H,6,8,10-11H2,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	132	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperone				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50109019 (Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chrom...) Show SMILES FC(F)(F)c1nc2ccc3CCC(CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C19H18F3N3O/c20-19(21,22)18-24-15-9-7-13-6-8-14(26-17(13)16(15)25-18)11-23-10-12-4-2-1-3-5-12/h1-5,7,9,14,23H,6,8,10-11H2,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	263	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperone				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair