BDBM50110290 CHEMBL14484::{4-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-butyl}-quinolin-4-yl-amine; Oxalic acid

SMILES: C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12

InChI Key: InChIKey=IDIWNMVUKUTAIK-UHFFFAOYSA-N

Data: 1 KI  1 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50110290   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50110290 (CHEMBL14484 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C27H35N3O/c1-6-19-30(20-7-1)21-8-22-31-24-14-12-23(13-15-24)9-4-5-17-28-27-16-18-29-26-11-3-2-10-25(26)27/h2-3,10-16,18H,1,4-9,17,19-22H2,(H,28,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Affinity for displacement of [125I]-iodoproxyfan from human histamine H3 receptors stably expressed in CHO cells				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50110290 (CHEMBL14484 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C27H35N3O/c1-6-19-30(20-7-1)21-8-22-31-24-14-12-23(13-15-24)9-4-5-17-28-27-16-18-29-26-11-3-2-10-25(26)27/h2-3,10-16,18H,1,4-9,17,19-22H2,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	79.4	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Activity at Histamine H3 receptor using functional H3 receptor assay on guinea pig ileum				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50110290 (CHEMBL14484 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C27H35N3O/c1-6-19-30(20-7-1)21-8-22-31-24-14-12-23(13-15-24)9-4-5-17-28-27-16-18-29-26-11-3-2-10-25(26)27/h2-3,10-16,18H,1,4-9,17,19-22H2,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atrium				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110290 (CHEMBL14484 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C27H35N3O/c1-6-19-30(20-7-1)21-8-22-31-24-14-12-23(13-15-24)9-4-5-17-28-27-16-18-29-26-11-3-2-10-25(26)27/h2-3,10-16,18H,1,4-9,17,19-22H2,(H,28,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50110290 (CHEMBL14484 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C27H35N3O/c1-6-19-30(20-7-1)21-8-22-31-24-14-12-23(13-15-24)9-4-5-17-28-27-16-18-29-26-11-3-2-10-25(26)27/h2-3,10-16,18H,1,4-9,17,19-22H2,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair