BindingDB PrimarySearch

BDBM50110676 CHEMBL280487::okadaic acid

SMILES: C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C

InChI Key: InChIKey=QNDVLZJODHBUFM-WFXQOWMNSA-N

Data: 20 IC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50110676
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Gallus gallus)	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literature				J Med Chem 40: 3199-206 (1997) Article DOI: 10.1021/jm960873x BindingDB Entry DOI: 10.7270/Q25Q4WS0
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R96A by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Instituto Universitario de Bio-Organica Antonio Gonzalez Curated by ChEMBL					Assay Description Inhibitory activity against serine/threonine protein phosphatase 1(PP1)				J Med Chem 47: 10-3 (2003) Article DOI: 10.1021/jm034189b BindingDB Entry DOI: 10.7270/Q20C4W88
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	Article	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle				Bioorg Med Chem Lett 3: 1029-1034 (1993) Article DOI: 10.1016/S0960-894X(00)80281-4 BindingDB Entry DOI: 10.7270/Q2125T5P
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	Article	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes				Bioorg Med Chem Lett 3: 1029-1034 (1993) Article DOI: 10.1016/S0960-894X(00)80281-4 BindingDB Entry DOI: 10.7270/Q2125T5P
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory concentration against Protein phosphatase 1 was determined				Bioorg Med Chem Lett 12: 391-3 (2002) BindingDB Entry DOI: 10.7270/Q2XS5VX8
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Gallus gallus)	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Concentration required to inhibit the action of protein phosphatase 2A				Bioorg Med Chem Lett 12: 391-3 (2002) BindingDB Entry DOI: 10.7270/Q2XS5VX8
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Observed inhibition activity against protein phosphatase 1 (PP1)				J Med Chem 40: 3199-206 (1997) Article DOI: 10.1021/jm960873x BindingDB Entry DOI: 10.7270/Q25Q4WS0
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Gallus gallus)	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Observed inhibition activity against protein phosphatase 2A (PP2A)				J Med Chem 40: 3199-206 (1997) Article DOI: 10.1021/jm960873x BindingDB Entry DOI: 10.7270/Q25Q4WS0
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D220V by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type H248N by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type N124D by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E275R by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R221S by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type Y272F by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D208A by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Gallus gallus)	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type C127S by compound was evalutade				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50110676 (CHEMBL280487 \| okadaic acid) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition activity against protein phosphatase 1 (PP1), activity taken from literature				J Med Chem 40: 3199-206 (1997) Article DOI: 10.1021/jm960873x BindingDB Entry DOI: 10.7270/Q25Q4WS0
University of California Curated by ChEMBL					More data for this Ligand-Target Pair