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BDBM50111408 1-(2-Pyridin-4-yl-2,8-diaza-spiro[4.5]decane-8-carbonyl)-piperidine-4-carboxylic acid::CHEMBL441017

SMILES: OC(=O)C1CCN(CC1)C(=O)N1CCC2(CCN(C2)c2ccncc2)CC1

InChI Key: InChIKey=UXEGVNNGYWFDQC-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50111408   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50111408
PNG
(1-(2-Pyridin-4-yl-2,8-diaza-spiro[4.5]decane-8-car...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)N1CCC2(CCN(C2)c2ccncc2)CC1
Show InChI InChI=1S/C20H28N4O3/c25-18(26)16-3-10-22(11-4-16)19(27)23-12-5-20(6-13-23)7-14-24(15-20)17-1-8-21-9-2-17/h1-2,8-9,16H,3-7,10-15H2,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



COR Therapeutics, Inc.

Curated by ChEMBL


Assay Description
In vitro activity to block the binding of fibrinogen to purified human fibrinogen receptor.


Bioorg Med Chem Lett 12: 1103-7 (2002)


BindingDB Entry DOI: 10.7270/Q2H131BN
More data for this
Ligand-Target Pair