BDBM50111625 6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-benzothiazol-2-one::CHEMBL15941
SMILES: Cn1c2ccc(CCCCN3CCN(Cc4ccccc4)CC3)cc2sc1=O
InChI Key: InChIKey=PFEUKVRZIQOBBQ-UHFFFAOYSA-N
Data: 8 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Displacement of [3H]-ketanserin from rat cortex 5-HT3 receptor | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Compound was evaluated in vitro for its binding affinity towards Sigma opioid receptor type 1 by using [3H]- (+)-pentazocine as radioligand | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Displacement of [3H]-prazosin from rat cortex membrane 5-hydroxytryptamine 1A receptor | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (RAT) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | <100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Displacement of [3H]-ketanserin from rat cortex 5-HT3 receptor | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from rat hippocampus membrane 5-hydroxytryptamine 2A receptor | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Displacement of [3H]-ketanserin from rat cortex 5-HT3 receptor | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Displacement of [3H]- raclopride from rat striatum Dopamine receptor D2 | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50111625 (6-[4-(4-Benzyl-piperazin-1-yl)-butyl]-3-methyl-3H-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Compound was evaluated in vitro for its binding affinity towards Muscarinic acetylcholine receptor M1 by displacing [3H]- telenzepine from rat brain ... | Bioorg Med Chem Lett 12: 1149-52 (2002) BindingDB Entry DOI: 10.7270/Q2G44PM6 | |||||||||||
More data for this Ligand-Target Pair |