BDBM50112354 CHEMBL472940
SMILES: Oc1ccc2ccccc2c1SSc1c(O)ccc2ccccc12
InChI Key: InChIKey=RFAXLXKIAKIUDT-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Serine/threonine-protein kinase PAK6 (Homo sapiens (Human)) | BDBM50112354 (CHEMBL472940) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of full length human PAK6 assessed as phosphate incorporation onto MBP preincubated for 5 mins followed by Cdc42, MBP, and mixture of ATP ... | ACS Med Chem Lett 6: 776-81 (2015) BindingDB Entry DOI: 10.7270/Q25X2BQS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK7 (Homo sapiens (Human)) | BDBM50112354 (CHEMBL472940) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of full length PAK5 (unknown origin) expressed in HEK293 cells assessed as phosphate incorporation onto MBP preincubated for 5 mins follow... | ACS Med Chem Lett 6: 776-81 (2015) BindingDB Entry DOI: 10.7270/Q25X2BQS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM50112354 (CHEMBL472940) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PAK Research Center Curated by ChEMBL | Assay Description Inhibition of PAK1 (unknown origin) | Eur J Med Chem 142: 229-243 (2017) Article DOI: 10.1016/j.ejmech.2017.07.043 BindingDB Entry DOI: 10.7270/Q21J9DG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM50112354 (CHEMBL472940) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Non-ATP competitive inhibition of full-length human PAK1 assessed as phosphate incorporation onto MBP preincubated for 5 mins followed by Cdc42, MBP,... | ACS Med Chem Lett 6: 776-81 (2015) BindingDB Entry DOI: 10.7270/Q25X2BQS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM50112354 (CHEMBL472940) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PAK4 kinase domain (300 to 591) (unknown origin) assessed as phosphate incorporation onto MBP preincubated for 5 mins followed by Cdc42... | ACS Med Chem Lett 6: 776-81 (2015) BindingDB Entry DOI: 10.7270/Q25X2BQS | |||||||||||
More data for this Ligand-Target Pair |