BDBM50112374 4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1-(3-chloro-phenyl)-piperazin-2-one::CHEMBL23135

SMILES: Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2ccccc2)CC1=O

InChI Key: InChIKey=XYYAXYGYXCQAEJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50112374 (4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...) Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2ccccc2)CC1=O Show InChI InChI=1S/C27H25ClN4O/c28-24-7-4-8-25(15-24)32-14-13-30(19-27(32)33)18-26-16-29-20-31(26)17-21-9-11-23(12-10-21)22-5-2-1-3-6-22/h1-12,15-16,20H,13-14,17-19H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50112374 (4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...) Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2ccccc2)CC1=O Show InChI InChI=1S/C27H25ClN4O/c28-24-7-4-8-25(15-24)32-14-13-30(19-27(32)33)18-26-16-29-20-31(26)17-21-9-11-23(12-10-21)22-5-2-1-3-6-22/h1-12,15-16,20H,13-14,17-19H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50112374 (4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...) Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2ccccc2)CC1=O Show InChI InChI=1S/C27H25ClN4O/c28-24-7-4-8-25(15-24)32-14-13-30(19-27(32)33)18-26-16-29-20-31(26)17-21-9-11-23(12-10-21)22-5-2-1-3-6-22/h1-12,15-16,20H,13-14,17-19H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair