BDBM50112376 1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-3H-imidazol-4-ylmethyl}-piperazin-2-one::CHEMBL23163

SMILES: FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1

InChI Key: InChIKey=PUIQBGZLGGGFGO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112376   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50112376 (1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phe...) Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1 Show InChI InChI=1S/C27H23ClF3N5O/c28-22-2-1-3-23(12-22)36-11-10-34(17-26(36)37)16-24-14-32-18-35(24)15-19-4-9-25(33-13-19)20-5-7-21(8-6-20)27(29,30)31/h1-9,12-14,18H,10-11,15-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50112376 (1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phe...) Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1 Show InChI InChI=1S/C27H23ClF3N5O/c28-22-2-1-3-23(12-22)36-11-10-34(17-26(36)37)16-24-14-32-18-35(24)15-19-4-9-25(33-13-19)20-5-7-21(8-6-20)27(29,30)31/h1-9,12-14,18H,10-11,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	509	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50112376 (1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phe...) Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1 Show InChI InChI=1S/C27H23ClF3N5O/c28-22-2-1-3-23(12-22)36-11-10-34(17-26(36)37)16-24-14-32-18-35(24)15-19-4-9-25(33-13-19)20-5-7-21(8-6-20)27(29,30)31/h1-9,12-14,18H,10-11,15-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair