BDBM50112384 1-(3-Chloro-phenyl)-4-[3-(2'-methoxy-4'-trifluoromethyl-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one::CHEMBL22675

SMILES: COc1cc(ccc1-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1)C(F)(F)F

InChI Key: InChIKey=NKZRKBVNTOVNAA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50112384   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50112384 (1-(3-Chloro-phenyl)-4-[3-(2'-methoxy-4'-trifluorom...) Show SMILES COc1cc(ccc1-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1)C(F)(F)F Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-22(29(31,32)33)9-10-26(27)21-7-5-20(6-8-21)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50112384 (1-(3-Chloro-phenyl)-4-[3-(2'-methoxy-4'-trifluorom...) Show SMILES COc1cc(ccc1-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1)C(F)(F)F Show InChI InChI=1S/C29H26ClF3N4O2/c1-39-27-13-22(29(31,32)33)9-10-26(27)21-7-5-20(6-8-21)16-36-19-34-15-25(36)17-35-11-12-37(28(38)18-35)24-4-2-3-23(30)14-24/h2-10,13-15,19H,11-12,16-18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	392	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair