BDBM50112386 1-(3-Chloro-phenyl)-4-[3-(3'-trifluoromethyl-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one::CHEMBL283380

SMILES: FC(F)(F)c1cccc(c1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1

InChI Key: InChIKey=IJFYLVPPTKMDPU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50112386 (1-(3-Chloro-phenyl)-4-[3-(3'-trifluoromethyl-biphe...) Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C28H24ClF3N4O/c29-24-5-2-6-25(14-24)36-12-11-34(18-27(36)37)17-26-15-33-19-35(26)16-20-7-9-21(10-8-20)22-3-1-4-23(13-22)28(30,31)32/h1-10,13-15,19H,11-12,16-18H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	662	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50112386 (1-(3-Chloro-phenyl)-4-[3-(3'-trifluoromethyl-biphe...) Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C28H24ClF3N4O/c29-24-5-2-6-25(14-24)36-12-11-34(18-27(36)37)17-26-15-33-19-35(26)16-20-7-9-21(10-8-20)22-3-1-4-23(13-22)28(30,31)32/h1-10,13-15,19H,11-12,16-18H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50112386 (1-(3-Chloro-phenyl)-4-[3-(3'-trifluoromethyl-biphe...) Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C28H24ClF3N4O/c29-24-5-2-6-25(14-24)36-12-11-34(18-27(36)37)17-26-15-33-19-35(26)16-20-7-9-21(10-8-20)22-3-1-4-23(13-22)28(30,31)32/h1-10,13-15,19H,11-12,16-18H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair