BDBM50112388 19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114,18.08,12.023,27]hentriaconta-1(27),8,10,14(31),15,17,20(28),21,23,25-decaen-3-one::CHEMBL280181
SMILES: O=C1CN2CCN1c1cccc3ccc(Oc4cccc(Cn5cncc5CC2)c4)cc13
InChI Key: InChIKey=BJSYVDIHBYVMSH-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50112388 (19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 509 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter... | Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Bos taurus (bovine)) | BDBM50112388 (19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells. | Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB | |||||||||||
More data for this Ligand-Target Pair |