BDBM50112389 1-(3-Chloro-phenyl)-4-{3-[6-(4-chloro-phenyl)-pyridin-3-ylmethyl]-3H-imidazol-4-ylmethyl}-piperazin-2-one::CHEMBL23239

SMILES: Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1

InChI Key: InChIKey=VVIZAZQTPDADQG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50112389 (1-(3-Chloro-phenyl)-4-{3-[6-(4-chloro-phenyl)-pyri...) Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1 Show InChI InChI=1S/C26H23Cl2N5O/c27-21-7-5-20(6-8-21)25-9-4-19(13-30-25)15-32-18-29-14-24(32)16-31-10-11-33(26(34)17-31)23-3-1-2-22(28)12-23/h1-9,12-14,18H,10-11,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50112389 (1-(3-Chloro-phenyl)-4-{3-[6-(4-chloro-phenyl)-pyri...) Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1 Show InChI InChI=1S/C26H23Cl2N5O/c27-21-7-5-20(6-8-21)25-9-4-19(13-30-25)15-32-18-29-14-24(32)16-31-10-11-33(26(34)17-31)23-3-1-2-22(28)12-23/h1-9,12-14,18H,10-11,15-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM50112389 (1-(3-Chloro-phenyl)-4-{3-[6-(4-chloro-phenyl)-pyri...) Show SMILES Clc1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1 Show InChI InChI=1S/C26H23Cl2N5O/c27-21-7-5-20(6-8-21)25-9-4-19(13-30-25)15-32-18-29-14-24(32)16-31-10-11-33(26(34)17-31)23-3-1-2-22(28)12-23/h1-9,12-14,18H,10-11,15-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.				Bioorg Med Chem Lett 12: 1269-73 (2002) BindingDB Entry DOI: 10.7270/Q2T72GSB
					More data for this Ligand-Target Pair