BDBM50112790 1-(2-Ethoxy-phenyl)-4-{4-[3-(3-nitro-phenyl)-isoxazol-5-yl]-butyl}-piperazine; hydrochloride::CHEMBL537975
SMILES: CCOc1ccccc1N1CCN(CCCCc2cc([n-][o+]2)-c2cccc(c2)[N+]([O-])=O)CC1
InChI Key: InChIKey=QDWOSBADSCWLQX-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50112790 (1-(2-Ethoxy-phenyl)-4-{4-[3-(3-nitro-phenyl)-isoxa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science and Technology Curated by ChEMBL | Assay Description Displacement of the radioligand [3H]YM-09151-2 from cloned human Dopamine receptor D3 expressed in CHO cells | Bioorg Med Chem Lett 12: 1327-30 (2002) BindingDB Entry DOI: 10.7270/Q2C53MC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50112790 (1-(2-Ethoxy-phenyl)-4-{4-[3-(3-nitro-phenyl)-isoxa...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science and Technology Curated by ChEMBL | Assay Description Displacement of the radioligand [3H]spiperone from the cloned human dopamine receptor D4 expressed in CHO cells | Bioorg Med Chem Lett 12: 1327-30 (2002) BindingDB Entry DOI: 10.7270/Q2C53MC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50112790 (1-(2-Ethoxy-phenyl)-4-{4-[3-(3-nitro-phenyl)-isoxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science and Technology Curated by ChEMBL | Assay Description Displacement of the radioligand [3H]spiperone from the cloned human Dopamine receptor D2 long expressed in CHO cells | Bioorg Med Chem Lett 12: 1327-30 (2002) BindingDB Entry DOI: 10.7270/Q2C53MC8 | |||||||||||
More data for this Ligand-Target Pair |