Found 10 hits for monomerid = 50112818 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol as substrate preincubated for 15 mins followed by ATP addition measured after 1 h... |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta (unknown origin) using phosphatidylinositol as substrate preincubated for 15 mins followed by ATP addition measured after 1 hr... |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (unknown origin) using PI or PIP2:PS as substrate by TR-FRET assay |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta (unknown origin) using PI or PIP2:PS as substrate by TR-FRET assay |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI4Kbeta (unknown origin) |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated human PI3Kbeta expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISA |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated human PI3Kgamma expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISA |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of Vps34 (unknown origin) |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of dofetilide binding to human ERG |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50112818
(CHEMBL3609521)Show SMILES CN(C)C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C21H30N6O2S2/c1-21(2,3)18-24-14-13(30-18)7-6-12-16(14)31-19(23-12)25-20(29)27-9-8-11(10-26(4)5)15(27)17(22)28/h11,15H,6-10H2,1-5H3,(H2,22,28)(H,23,25,29)/t11-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated human PI3Kalpha expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISA |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |