Found 7 hits for monomerid = 50112831 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta (unknown origin) using phosphatidylinositol as substrate preincubated for 15 mins followed by ATP addition measured after 1 hr... |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (unknown origin) using PI or PIP2:PS as substrate by TR-FRET assay |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta (unknown origin) using PI or PIP2:PS as substrate by TR-FRET assay |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol as substrate preincubated for 15 mins followed by ATP addition measured after 1 h... |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated human PI3Kbeta expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISA |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated human PI3Kgamma expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISA |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50112831
(CHEMBL3609518)Show SMILES C[C@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C |r| Show InChI InChI=1S/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated human PI3Kalpha expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISA |
Bioorg Med Chem Lett 25: 3575-81 (2015)
BindingDB Entry DOI: 10.7270/Q2DF6SZ5 |
More data for this Ligand-Target Pair | |