BDBM50112935 (2-Chloro-4,6-dimethyl-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-amine::CHEMBL29185::N-(2-chloro-4,6-dimethylphenyl)imidazo[1,5-a]quinoxalin-4-amine

SMILES: Cc1cc(C)c(Nc2nc3ccccc3n3cncc23)c(Cl)c1

InChI Key: InChIKey=PICOUCFUAAEMBT-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112935   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50112935 ((2-Chloro-4,6-dimethyl-phenyl)-imidazo[1,5-a]quino...) Show SMILES Cc1cc(C)c(Nc2nc3ccccc3n3cncc23)c(Cl)c1 Show InChI InChI=1S/C18H15ClN4/c1-11-7-12(2)17(13(19)8-11)22-18-16-9-20-10-23(16)15-6-4-3-5-14(15)21-18/h3-10H,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...				Bioorg Med Chem Lett 12: 1361-4 (2002) BindingDB Entry DOI: 10.7270/Q2R78DJ1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50112935 ((2-Chloro-4,6-dimethyl-phenyl)-imidazo[1,5-a]quino...) Show SMILES Cc1cc(C)c(Nc2nc3ccccc3n3cncc23)c(Cl)c1 Show InChI InChI=1S/C18H15ClN4/c1-11-7-12(2)17(13(19)8-11)22-18-16-9-20-10-23(16)15-6-4-3-5-14(15)21-18/h3-10H,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of Lck				J Med Chem 51: 1179-88 (2008) Article DOI: 10.1021/jm070654j BindingDB Entry DOI: 10.7270/Q29Z95RD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50112935 ((2-Chloro-4,6-dimethyl-phenyl)-imidazo[1,5-a]quino...) Show SMILES Cc1cc(C)c(Nc2nc3ccccc3n3cncc23)c(Cl)c1 Show InChI InChI=1S/C18H15ClN4/c1-11-7-12(2)17(13(19)8-11)22-18-16-9-20-10-23(16)15-6-4-3-5-14(15)21-18/h3-10H,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Evaluated for inhibition of human p56 Lck tyrosine kinase				J Med Chem 47: 2534-49 (2004) Article DOI: 10.1021/jm0304358 BindingDB Entry DOI: 10.7270/Q2KH0P3P
					More data for this Ligand-Target Pair