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BDBM50114231 (4-{4-[3-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-ureido]-phenoxy}-phenyl)-carbamic acid ethyl ester::CHEMBL41310

SMILES: CCOC(=O)Nc1ccc(Oc2ccc(NC(=O)Nc3cc(nn3C)C(C)(C)C)cc2)cc1

InChI Key: InChIKey=AMASUPSHOBDCLG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50114231   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50114231
PNG
((4-{4-[3-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-u...)
Show SMILES CCOC(=O)Nc1ccc(Oc2ccc(NC(=O)Nc3cc(nn3C)C(C)(C)C)cc2)cc1
Show InChI InChI=1S/C24H29N5O4/c1-6-32-23(31)26-17-9-13-19(14-10-17)33-18-11-7-16(8-12-18)25-22(30)27-21-15-20(24(2,3)4)28-29(21)5/h7-15H,6H2,1-5H3,(H,26,31)(H2,25,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 33n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2


Bioorg Med Chem Lett 12: 1559-62 (2002)


BindingDB Entry DOI: 10.7270/Q2CV4H28
More data for this
Ligand-Target Pair