BDBM50114444 2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL297423

SMILES: Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN

InChI Key: InChIKey=BPZCCWRPDHSWCL-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50114444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kallikrein-1 (KLK1) (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against kallikrein				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against trypsin				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against thrombin				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against plasmin				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair
Vitamin K-dependent protein C (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against activated protein C				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against plasmin				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50114444 (2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...) Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1CN Show InChI InChI=1S/C28H25N5O3S/c1-18-14-26(33(32-18)25-16-21-7-3-2-6-20(21)15-22(25)17-29)28(34)31-23-12-10-19(11-13-23)24-8-4-5-9-27(24)37(30,35)36/h2-16H,17,29H2,1H3,(H,31,34)(H2,30,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against coagulation factor Xa				Bioorg Med Chem Lett 12: 1651-5 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RFZ
					More data for this Ligand-Target Pair