BDBM50114808 CHEMBL3609753

SMILES: Cc1cn(cn1)-c1ccc(cc1OC(F)(F)F)-c1cn(nn1)C1CCc2c(F)cccc2C(CC(F)(F)F)C1=O

InChI Key: InChIKey=QZKUUTWEUPOQOZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50114808   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human))	BDBM50114808 (CHEMBL3609753) Show SMILES Cc1cn(cn1)-c1ccc(cc1OC(F)(F)F)-c1cn(nn1)C1CCc2c(F)cccc2C(CC(F)(F)F)C1=O Show InChI InChI=1S/C26H20F7N5O2/c1-14-11-37(13-34-14)21-7-5-15(9-23(21)40-26(31,32)33)20-12-38(36-35-20)22-8-6-17-16(3-2-4-19(17)27)18(24(22)39)10-25(28,29)30/h2-5,7,9,11-13,18,22H,6,8,10H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid be...				Bioorg Med Chem Lett 25: 3495-500 (2015) BindingDB Entry DOI: 10.7270/Q2125VFP
					More data for this Ligand-Target Pair
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human))	BDBM50114808 (CHEMBL3609753) Show SMILES Cc1cn(cn1)-c1ccc(cc1OC(F)(F)F)-c1cn(nn1)C1CCc2c(F)cccc2C(CC(F)(F)F)C1=O Show InChI InChI=1S/C26H20F7N5O2/c1-14-11-37(13-34-14)21-7-5-15(9-23(21)40-26(31,32)33)20-12-38(36-35-20)22-8-6-17-16(3-2-4-19(17)27)18(24(22)39)10-25(28,29)30/h2-5,7,9,11-13,18,22H,6,8,10H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid be...				Bioorg Med Chem Lett 25: 3495-500 (2015) BindingDB Entry DOI: 10.7270/Q2125VFP
					More data for this Ligand-Target Pair