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SMILES: [#6]-[#8]-c1ccccc1-[#6]-1-[#6]-[#6](=[#7]\[#7]=[#6](\[#7])-[#7])-c2c(-[#6])ccnc2-[#6]-1

InChI Key: InChIKey=RADUPKWPRJQGHY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50115253   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/hydrogen exchanger 1


(Rattus norvegicus)		BDBM50115253
PNG
(CHEMBL555103 | N-[7-(2-methoxyphenyl)-4-methyl-5,6...)
Show SMILES [#6]-[#8]-c1ccccc1-[#6]-1-[#6]-[#6](=[#7]\[#7]=[#6](\[#7])-[#7])-c2c(-[#6])ccnc2-[#6]-1 |w:11.12|
Show InChI InChI=1S/C18H21N5O/c1-11-7-8-21-14-9-12(13-5-3-4-6-16(13)24-2)10-15(17(11)14)22-23-18(19)20/h3-8,12H,9-10H2,1-2H3,(H4,19,20,23)
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n/an/a 100n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition

J Med Chem 45: 3009-21 (2002)


BindingDB Entry DOI: 10.7270/Q2V40VZN
More data for this
Ligand-Target Pair