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BDBM50115312 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (3,5-dichloro-phenyl)-amide::CHEMBL104862

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3cc(Cl)cc(Cl)c3)c2cc1OC

InChI Key: InChIKey=MXVZCCAUCHDFAJ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50115312   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115312
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C21H21Cl2N5O3/c1-30-18-10-16-17(11-19(18)31-2)24-12-25-20(16)27-3-5-28(6-4-27)21(29)26-15-8-13(22)7-14(23)9-15/h7-12H,3-6H2,1-2H3,(H,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 9.21E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation


J Med Chem 45: 3057-66 (2002)


BindingDB Entry DOI: 10.7270/Q2RX9BDP
More data for this
Ligand-Target Pair