BDBM50115314 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (2-nitro-phenyl)-amide::CHEMBL105689
SMILES: COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccccc3[N+]([O-])=O)c2cc1OC
InChI Key: InChIKey=DJCXBGBTOUKRNR-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50115314 (4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of Platelet-derived growth factor receptor beta phosphorylation | J Med Chem 45: 3057-66 (2002) BindingDB Entry DOI: 10.7270/Q2RX9BDP | |||||||||||
More data for this Ligand-Target Pair |