BDBM50115338 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid (4-tert-butyl-phenyl)-amide::CHEMBL105409

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(cc3)C(C)(C)C)c2cc1OC

InChI Key: InChIKey=VJGJRBKMUAJFQF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50115338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50115338 (4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...) Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(cc3)C(C)(C)C)c2cc1OC Show InChI InChI=1S/C25H31N5O2S/c1-25(2,3)17-6-8-18(9-7-17)28-24(33)30-12-10-29(11-13-30)23-19-14-21(31-4)22(32-5)15-20(19)26-16-27-23/h6-9,14-16H,10-13H2,1-5H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Platelet-derived growth factor receptor beta phosphorylation				J Med Chem 45: 3057-66 (2002) BindingDB Entry DOI: 10.7270/Q2RX9BDP
					More data for this Ligand-Target Pair